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akt inhibitor  (Tocris)


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    Tocris akt inhibitor
    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and <t>PI3K/AKT</t> signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB <t>of</t> <t>phospho-FAK</t> (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
    Akt Inhibitor, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/akt inhibitor/product/Tocris
    Average 93 stars, based on 32 article reviews
    akt inhibitor - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "Ezrin drives adaptation of monocytes to the inflamed lung microenvironment"

    Article Title: Ezrin drives adaptation of monocytes to the inflamed lung microenvironment

    Journal: Cell Death & Disease

    doi: 10.1038/s41419-024-07255-8

    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and PI3K/AKT signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB of phospho-FAK (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
    Figure Legend Snippet: A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and PI3K/AKT signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB of phospho-FAK (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .

    Techniques Used: Membrane, Activation Assay, Fluorescence, Activity Assay



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    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and <t>PI3K/AKT</t> signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB <t>of</t> <t>phospho-FAK</t> (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
    Akt Inhibitor, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    akt inhibitor iv hy 14971 medchemexpress  (MedChemExpress)
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    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and <t>PI3K/AKT</t> signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB <t>of</t> <t>phospho-FAK</t> (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
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    akt inhibitor iv  (Santa Cruz Biotechnology)
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    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and <t>PI3K/AKT</t> signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB <t>of</t> <t>phospho-FAK</t> (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
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    akt inhibitor iv  (Merck KGaA)
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    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and <t>PI3K/AKT</t> signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB <t>of</t> <t>phospho-FAK</t> (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
    Akt Inhibitor Iv, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    akt inhibitor akt inhibitor iv #124015  (Millipore)
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    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and <t>PI3K/AKT</t> signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB <t>of</t> <t>phospho-FAK</t> (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
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    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and <t>PI3K/AKT</t> signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB <t>of</t> <t>phospho-FAK</t> (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .
    S2827 Akt Inhibitor Iv Cruzcredit, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and PI3K/AKT signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB of phospho-FAK (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .

    Journal: Cell Death & Disease

    Article Title: Ezrin drives adaptation of monocytes to the inflamed lung microenvironment

    doi: 10.1038/s41419-024-07255-8

    Figure Lengend Snippet: A Schematic representation of ezrin signaling. Ezrin links plasma membrane (PM) and filamentous actin (F-actin) and adheres to the extracellular matrix (e.g., collagen) via integrin α/β. The activation of focal adhesion kinase leads to efficient cell spreading and adhesion, and PI3K/AKT signaling activation is required for cell survival. B Quantification of crystal violet absorbance emitted from adherent primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Absorbance values are relative to WT Untr. C Representative WB of phospho-FAK (pFAK, tyrosine 397), total FAK, phospho-AKT (pAKT, serine 473) and total AKT and densitometric analysis of pFAK and pAKT in primary BM monocytes of murine WT and Ezr -KO m untreated or treated with LPS (6 h). Bar graphs represent pFAK/FAK and pAKT/AKT ratios. Protein fold increase was normalized to β-actin and relative to untreated cells. D Quantification of the percentage of dead cells in primary BM monocytes of murine WT and Ezr -KO m , post-exposure to LPS. See also Fig. . E Relative fluorescence units measuring caspase3/7 activity in primary BM monocytes of murine WT and Ezr -KO m , untreated or treated with LPS at different time points. Data are represented as mean ± SEM from three independent experiments. Statistical analysis was performed using one-way ANOVA or Tukey’s test for multiple comparisons between the genotype and treatment conditions. * p < 0.05, ** p < 0.01 and **** p < 0.001. See also Supplementary Fig. .

    Article Snippet: In a set of experiments, BMD-Mφs were plated at the density of 200,000 cells/well (96 well plates) and treated with FAK inhibitor (PND 1186—1 μM, Tocris) or AKT inhibitor (LY 294002—10 μM, Tocris) for 24 h with continued incubation at 37 °C with 5% CO 2 .

    Techniques: Membrane, Activation Assay, Fluorescence, Activity Assay